Of course, I remember the music video with the missing children. MTV watching during my adolescence introduced me to this video but the song means so much more to me now. It's about being at an absolute low and there being no way of coming back from it and no one to help you. It's a hopeless feeling and one I'm sure many of us have felt at one time or another. These lyrics express that to me.
"I don't think that anybody that really loves that song thinks about the video that much." - Dave Pirner of Soul Asylum explains to us how the iconic "missing children" video for the Grammy Award winning "Runaway Train" had very little to do with the song itself, but ended up defining it anyway: http://www.songfacts.com/blog/interviews/dave_pirner_of_soul_asylum/