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Opie (Gregg Hughes, born May 23, 1963) and Anthony (Anthony Cumia, born April 26, 1961) are the hosts of The Opie & Anthony Show, a talk radio program airing in The United States and Canada on XM Satellite Radio and Sirius Satellite Radio. It is co-hosted by stand up comedian Jim Norton. The show is currently based in New York City; it was previously on WXRK-FM and WNEW-FM in New York, and before that, on WAAF-FM in Boston. The Opie and Anthony Show has been acknowledged by Jay Leno as "the most popular show in the history of satellite radio" during Jim Norton's appearance on the Tonight Show with Jay Leno in March 2009.

The Opie & Anthony Show airs weekdays live from 6am through 12pm ET exclusively on XM Radio Channel 202 and Sirius Radio Channel 197 "The Virus". Unless the live show is running long, a "worst-of" segment is broadcast from 11am to 12pm. Replays are available throughout the day on their XM and Sirius channels.

On April 26, 2006, Opie and Anthony returned to the terrestrial airwaves after a four year absence, replacing CBS Radio's short-lived David Lee Roth Show, which aired mainly on the eastern coast of the United States. The terrestrial part of the show ran until March 9, 2009, when WXRK-FM flipped formats from rock to Top 40.

Gregg "Opie" Hughes and Anthony Cumia were raised on Long Island, New York, in Centerport and Elwood respectively. Hughes graduated from SUNY Geneseo and for the next seven years, interned and worked at several upstate New York radio stations such as WCMF in Rochester (where he first worked for Brother Wease) and WUFX in Buffalo. Opie eventually found his way back home to rock station WBAB on his native Long Island. Although not initially doing a talk-show, Hughes did experiment with certain talk elements, including a recurring character named "Spuds Buckley". Cumia was a high school dropout barely earning a living as an HVAC duct worker when he began performing songs with his brother Joe. Cumia showed remarkable skills at doing impressions. In August 1994, Hughes received an entry during an O.J. Simpson parody song contest. The song was titled "Gonna Electric Shock OJ" (sung to the tune of Otis Redding's "(Sittin' On) The Dock of the Bay") by a local band known as Rotgut, of which Cumia was the lead singer. The song was a hit on Hughes' show, and he invited the Cumia brothers to the studio to play live in September 1994. This sparked several more appearances, where "Ant & Brother Joe" jumped at any opportunity to be on the air. In December 1994, Cumia also appeared on The Howard Stern Show during an impression contest in which he imitated Jackie the Jokeman, Beavis and Butt-head, and Sam Kinison. Soon afterward, Hughes and Cumia became a radio team. Hughes' show was called "The Nighttime Attitude", which aired from 8 pm-midnight on WBAB. Shortly after Cumia's arrival, he and Hughes requested that the show be moved to morning or afternoon drive, the two most listened-to timeslots in radio. When the station refused, Hughes and Cumia moved the show to afternoon drive on WAAF in Boston, where they premiered on March 27, 1995 as Opie & Anthony (O&A).


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