The Brendan's Death Song Songfacts says: Following the departure of guitarist John Frusciante in 2009, the Red Hot Chili Peppers recruited longtime associate Josh Klinghoffer to replace him. Klinghoffer began writing and jamming with the band on October 12, 2009, the same day that Brendan Mullen - the LA nightclub owner who gave the band their first break - passed away. This ballad is a tribute to Mullen.
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