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"Oh, Sister" became a concert favorite during the fall tour preceding Desire's release. Tim Riley noted that it was the first time Dylan had invoked God as a method of wooing a woman, and that with Emmylou Harris, the song became a discourse on the fragility of love. Harris's vocal on the final mix was actually overdubbed a day later, one of the few overdubs made during the Desire sessions.

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Lyrics

Oh, sister, when I come to lie in your arms
You should not treat me like a stranger
Our Father would not like the way that you act
And you must…

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