She grew up in the Samtskhe-Javakheti region of southern Georgia. In 1952 she moved with her family to Yerevan, where she attended a secondary music school. She entered the Yerevan State Musical Conservatory in 1957 and her singing talent soon became clear.
Lusine began her professional career in 1962. In a very short time her fame spread and extended outside of Armenia. She embarked upon her International tours that took her to: Europe, Canada, the United States, Argentina, Vrugay and the Middle East. Lusine s repertoire was extensive. She sang in 15 languages, with a very varied and rich selection of works by Bach, Handel, Mozart, Verdi, Schubert and many other western composers.
From 1970 to 1983 Zakaryan was a soloist with the symphony orchestra of Armenian TV and Radio. She also sang in the choir of the Armenian Apostolic Church's Holy See at the Echmiadzin Cathedral, and it is for her magnificent rendition of centuries-old Armenian spiritual hymns that she is now most remembered for.
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