"Die by the Drop" is the first single off of The Dead Weather's second album Sea of Cowards. It was released on the March 30, 2010 in the United States and was released on the 25th April in the UK. The single includes the B-side "Old Mary".
The song's music video was directed by Italian/Canadian photographer and director Floria Sigismondi, who previously helmed the White Stripes' Blue Orchid clip. She also directed the 2010 Kristen Stewart Runaways movie.