Matt Bellamy has said the song was inspired by a dream he had in which he was in desert and there were giant blades swinging from the sky.
The first time Micro Cuts was played live, it featured different lyrics in place of "Micro waves me insane, A blade cuts in your brain" and the chorus. Early live versions featured an extended outro that featured parts of the song Execution Commentary, as well as extra lyrics.
Hands are red with your blame
Megaphone screaming my name
Whimpers someone I should've loved
Souls weeping above