Symphony of Destruction is one of the most famous Megadeth songs. It's from their 1992 double platinum selling album, Countdown to Extinction.
Music video: http://www.youtube.com/watch?v=67bTpVQfB6U
The song has been covered by lots of bands and has featured in numerous video games.
List of bands:
* Al Jourgensen with Trent Reznor
* Arch Enemy
* Black Warrant
You take a mortal man
And put him in control
Watch him become a god
Watch people's heads a'roll