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"Of Mice and Men" was selected as the second video from the album, in this video the new Megadeth line up is performing - Dave Mustaine, Shawn Drover, Glen Drover and James MacDonough. The majority of the video was shot on January 20, 2005 in Los Angeles. Numbers of Megadeth fans turned up to be in the video through a "contest" held by Sanctuary Group who funded the video. The video follows the autobiographical lyric of the song which tells the life of Dave Mustaine between the age of 17 to 25 years old. The title of the song is taken from the famous novel of the same name.

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