According to the Who Says You Can't Go Home Songfacts, this song is about remaining true to your roots no matter where life takes you. For Bon Jovi, their home is New Jersey, where they are a great source of pride. Despite their travels, that is always their home and they will always be welcomed back.
In 2008, Jon Bon Jovi talked about the song after Republican vice-presidential candidate Sarah Palin used it at some…
I spent twenty years tryin' to get out of this place
I was lookin' for somethin' I couldn't replace
I was runnin' away from the only thing I've ever known