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Antigen Shift is an electro-industrial band hailing from Ottawa, Ontario, Canada led by Nick Thériault. The band takes its name from the medical phenomenon.

Thériault began experimenting with electronic sounds in 2000, combining world beat music with haunting, sometimes distorted, rhythmic, richly-textured soundscapes. Antigen Shift released Primary Causation in 2001, a limited edition CD that was sold at the first installment of the Providence Noise Festival. The next year, Conjugate (a split with British band Detritus) was released on UK label Fleshmadeword. Also in 2002, Antigen Shift released a split recording with fellow Canadian band Iszoloscope, titled The Blood Dimmed Tide. Implicit Structures, the first Antigen Shift full-length CD, was released on Frozen Empire Media in 2003. Several live shows were played in support of the CD, including dates with Gridlock and the Swedish artist Tarmvred. Belgium-based label Spectre released This Moment of Cold Remembering, the band's first vinyl recording, in 2003 as well. In 2004 Frozen Empire Media released the EP Next to Departed. This recording used piano and synthesized melodies. In 2006, Antigen Shift's second full-length album, The Way of the North, was released on Ad Noiseam. He is currently working on his sixth release.

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