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In October 2001, a group of popular recording artists under the name "Artists Against AIDS Worldwide" released an album containing multiple versions of "What's Going On" to benefit AIDS programs in Africa and other impoverished regions. Jermaine Dupri and Bono produced the radio single version, whose performers included Britney Spears, Backstreet Boys, Gwen Stefani, Christina Aguilera, *NSYNC, Destiny's Child, Jennifer Lopez, Gaye's own daughter Nona, and many other popular artists. The album contained that single along with 8 additional remixes. The song was recorded shortly before the September 11, 2001 attacks, and it was decided afterwards that a portion of the song's proceeds would benefit the American Red Cross's September 11th fund, as well as Artists Against AIDS Worldwide.

Artists Against AIDS Worldwide lineup

* Bono
* Britney Spears
* Christina Aguilera
* Jennifer Lopez
* Gwen Stefani
* Mary J. Blige
* Backstreet Boys
* Destiny's Child
* Sean Combs
* Lil Kim
* Jermaine Dupri (producer)
* Fred Durst of Limp Bizkit
* Eve
* Monica
* Nelly Furtado
* Nona Gaye
* Darren Hayes
* Ja Rule
* Alicia Keys
* Aaron Lewis of Staind
* Nas
* Nelly
* Michael Stipe of R.E.M.
* Usher
* Wyclef Jean

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